avicenna’s concept of cardiovascular drug targeting in medicamenta cordialia

the relationship between academic self-concept and academic achievement in english and general subjects of the students of high school

according to research, academic self-concept and academic achievement are mutually interdependent. in the present study, the aim was to determine the relationship between the academic self-concept and the academic achievement of students in english as a foreign language and general subjects. the participants were 320 students studying in 4th grade of high school in three cities of noor, nowshah...

RAMADAN AND CARDIOVASCULAR DRUG USE

Drug Design Concept in Ocular Drug Delivery

Ocular administration of the drug is primarily associated with the need to treat ophthalmic diseases and is not regarded as a means for gaining systemic drug action. Major classes of drugs used are miotics, mydriatics/cyclopegics, anti-inflammatory, antiinfectives, surgical adjutants and diagnostics, which are all meant for local therapy. Systemic action by using eye as a portal is generally av...

Organelle targeting: third level of drug targeting

Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the ther...

Targeting Rho in cardiovascular disease.

What began as molecular switches linking cell surface receptors to the reorganization of the actin cytoskeleton has now emerged as an important mediator of cardiovascular disease. The lowmolecular-weight GTPases of the Rho family have appeared with increasing frequency in the cardiovascular literature. This interest stems from two seemingly opposite disciplines. From a basic science perspective...

Leukemic stem cells: from metabolic pathways and signaling to a new concept of drug resistance targeting.

Cancer stem cells are a small subset of cancer cells constituting a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. These cells are identified by specific stem cell markers: antigens, molecules and signaling pathways. Transcription factors and molecules associated with oncogenesis, such as NF-kappaB, Bmi-1, Notch, WNT beta-catenin, Sonic hedge...